|
KMID : 0356420090270030212
|
|
Journal of Korean Andrology
2009 Volume.27 No. 3 p.212 ~ p.216
|
|
|
Is it Appropriate to Lower the Prostate Specific Antigen Cut-off Value to 2.5 ng/ml for Prostate Biopsy in Korean?
|
|
Yoon Byung-Il
Kim Su-Jin
Cho Hyuk-Jin
Hong Sung-Hoo
Sohn Dong-Wan
Lee Ji-Youl
Hwang Tae-Kon
Kim Sae-Woong
|
|
|
Abstract
|
|
|
Purpose: Currently many clinicians have recommendsprostate biopsy when the level of prostate specific antigen (PSA) is higher than 4.0 ng/ml. However, recently the prostate cancer detection rates werereported to be about 20% at PSA level 2.5 to 4.0 ng/ml. Therefore, an increasing amount of hospitals have recommends lowering the PSA cut off level to 2.5 ng/ml. We retrospectively evaluated the prostate cancer detection rate and pathologic characteristics of patients with PSA level of 2.5 to 4.0 ng/ml and we compared this with the patients who had PSA level in the range of 4.1 to 10.0 ng/ml.
Materials and Methods: We analyzed the data of 515 patients who received prostate biopsy in the range of PSA level 2.5 to 10 ng/ml. The clinical characteristics, cancer detection rate and pathologic findings of the biopsy were compared between the PSA 2.5-4.0 ng/ml group and PSA 4.1-10.0 ng/ml group.
Results: Cancer detection rates in patients who underwent biopsy were 18.1% and 22.4% at PSA 2.5 to 4.0 and 4.1 to 10.0 ng/ml, respectively. Mean Gleason scores were found 6.4±0.5 and 6.6±0.7 and high grade cancers with Gleason score 7 or more were found in 50% and 58.4% of patients with cancer with PSA 2.5 to 4.0 and 4.1 to 10.0 ng/ml, respectively. There were no significant difference between the 2 groups in cancer detection rates and pathologic findings on biopsy including mean Gleason score and high grade cancers with Gleason score 7 or more between two groups.
Conclusion: There were no significant difference in cancer detection rates and pathologic findings between PSA 2.5-4 ng/ml group and PSA 4.1-10 ng/ml group. These results suggest that a lower PSA cutoff should be considered as an indication for prostate biopsy in the Korean population.
|
|
|
KEYWORD
|
|
|
Prostate cancer, Prostate-specific antigen, Biopsy
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|